General Toxicology

Vectura Fertin Pharma Laboratories conducts our studies in accordance with GLP standards and internationally accepted guidelines. We are able to support dose range finding studies and repeated dose toxicity studies to identify acute to chronic and carcinogenicity toxicity effects using various routes of administration that is most suited to your research needs. In addition, we also conduct in vivo genotoxicity studies.

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Preclinical GLP General Toxicology 

Acute Toxicity studies

  • Dose range finding studies to evaluate MTD and acute toxicity effects

Sub- acute and sub-chonic Toxicity Studies 

  • Repeated dose studies to evaluate the sub-acute and sub-chronic toxicity effects over a 28-day or 90-day study duration

Chronic and carcinogenicity Toxicity Studies 

  • 12 or 24-months mouse or rat studies 

In Vivo GLP Genotoxicity Studies 

Mammalian Erythrocyte Micronucleus Test (OECD TG474)

Principal endpoints include:

  • Frequency of micronucleated immature erythrocytes in bone marrow or peripheral blood samples
  • Frequency of mature erythrocytes that contain micronuclei in peripheral blood samples
  • In-life assessments include body weight monitoring and clinical observations.

Routes of Administration

We offer the following standard routes of administration for general toxicology studies and are happy to advise further on the most suitable route to meet your needs.

  • Oral (gavage, or delivery in food or water)
  • Inhalation
  • Intratracheal (intubation or instillation)
  • Intranasal
  • Intramuscular
  • Intravenous
  • Intraperitoneal
  • Subcutaneous